Research is undertaken at the CADE Clinic so as to improve the quality of life for people with mood and anxiety disorders. Studies are conducted using five unique interdisciplinary approaches, with the ultimate goal of discovering new scientific methods to enhance clinical management for the benefit of our patients. The CADE Clinic utilises the latest state-of-the-art technologies and facilities in the areas of treatment, and clinical research initiatives as well as neuroimaging, electrophysiology and neuropsychology.

Volunteers needed

If you would like to participate as a subject in any research study please email the CADE Clinic directly and indicate which study you would like to participate in. Please read the study requirements carefully. You are welcome to respond simply to learn more about the project. A response from you does not imply any obligation to participate. You are free not to participate or to withdraw from any study at any time.

Current Studies



Neuropsychological testing involves examining cognitive abilities such as memory, attention and learning, as well as testing other more specific skills, such as problem solving and reaction time. In mood and anxiety disorders some of these skills can be compromised by episodes of illness and as yet the precise mechanisms by which this occurs are unclear. New psychological research in the CADE Clinic is focused on investigating the exact nature of deficits that occur in mood and anxiety disorders, in particular measuring these accurately and correlating findings with neurobiological markers.

Current neuropsychology projects include:

• Investigating the cognitive profile of mood disorders

• Examining the neuropsychology of anxiety disorders

• Defining the neuropsychological profile of adolescents with bipolar disorder


Clinical Research

The CADE Clinic is a hospital-based University of Sydney Clinic with expertise in the diagnosis and management of mood and anxiety disorders. Embedded within clinical assessments that are conducted within the clinic are research studies examining a number of key aspects of these illnesses. Individuals attending the clinic complete clinical assessments and undergo structural interviews with a number of investigators. Currently researchers are examining aspects of phenomenology, and the diagnosis and treatment of depression and bipolar disorder. Projects examining specific populations or disorders are also being conducted and individuals attending the clinic, if suitable, may be approached for inclusion in future research studies.  


Treatment Studies

The Relationship between Avoidant Personality Disorder and Social Phobia

We are not currently recruiting for this project. Results will be posted when available.


A New Approach to Bipolar Depression 

We are not currently recruiting for this project.


Psychological Treatment for Adolescents

We are not currently recruiting for this project.



The neuroimaging laboratory at the CADE Clinic employs the latest multimodal imaging techniques, to test critical hypotheses about the workings of the brain. The laboratory currently has research projects using functional MRI, spectroscopy, diffusion tensor imaging and structural imaging. If you would like to volunteer to participate in any of the neuroimaging research projects, click here.

•    Sensorimotor gating in hypomanic bipolar disorder
•    An fMRI investigation of Theory of Mind in Bipolar Disorder
•    A study of face recognition in Bipolar II patients
•   White matter abnormalities in Bipolar Disorder: A DTI study

•   Testing the glutathione dysfunction hypothesis: High-field proton MRS


Electrophysiology Studies


Electrophysiological research makes use of an EEG/ERP laboratory that is dedicated to the study of cognitive brain mechanisms. The electrophysiology laboratory has specialised equipment for behavioural and electrophysiological recording, high frame-rate eye movement apparatus as well as integrated heart rate, skin conductance and respiratory rate indices. The research goals of the laboratory revolve around the understanding of the neural mechanisms that underly perception, attention, and multisensory integration in the human brain.




   AvPD Social Phobia